Study of students’ academic performance has been the most important indicator in higher educational system. Hence, the goal of this study was to explore the relationship between quality of life and scientific performance of students at Gorgan University of medical sciences. This Analytical study was done through using academic performance questionnaire which its face and content validity as well as reliability were determined and confirmed; moreover, the quality of life SF12 was completed by 126 samples with at least 3-year College experience. Samples were selected by random sampling design and proportional to the number of students per Colleges in 1392; noon of population had known-physical or known-mental illness and traumatic event within 3 months; none was graduated during study period. In addition, data analysis was done by statistical software SPSS and frequency, and Pearson Correlation Coefficient and stepwise regressions statistical techniques were in the 95% confidence level. Afterward, results indicated that between students’ quality of life and academic performance was positive significant correlation with correlation coefficient of 0/45; so the higher scores of quality of life pointed out higher level of academic performance. Moreover, mental quality of life and academic performance of students showed positive significant correlation, but between the physical quality of life and the academic performance of students wasn’t a correlation; academic performance (Y) of students can be estimated using the predicted formula (Y= 42 + 0 / 3 X) by the psychological Quality of life (X) scores. Totally, results indicated that there would be a relationship between the quality of life and the academic performance of students.