The present study was performed on propose of assessment and comparison of stress, depression and emotional intelligence among medical students and engineering students This cross-sectional study was done on 383 student in 1st to 3rd year students of medicine, dentistry, nursing, computer science, electronics, and materials, 60 members of each subject were selected and classified randomly. The emotional intelligence questionnaire (SSEIT-33), the obtained stress (PSS-10) and the Beck Depression Inventory (BDI-21) were used to assess the significance of the data which was examined and analized utilizing Pearson's correlation coefficient, chi-square, and t are independent groups, were analyzed. The mean score of emotional intelligence in the general population was121.4±13.4, the mean score of experienced strees score was 17.5±6.8 ,and the mean score of Beck depression test was 10.28±8.7. In addition, a significant negative correlation was observed between emotional intelligence and stress (r = - 0.417, p = 0.01) and between emotional intelligence and depression(r = -0.372, p = 0.01). There was no significant difference between students of different disciplines in terms of emotional intelligence, stress and depression(p> 0.05); moreover, the relationship between age, gender, marital status and education level of emotional intelligence, stress and depression was not significant (p> 0.05). In concultion, the results showed that emotional intelligence was effective to lessen stress and depression, and the difference regarding to these technical components was not noticed between medical students and engineering students. . Therefore, the promotion of emotional intelligence in medical and engineering students appears to be necessary.